来自加工人参的细胞毒性达玛烷糖苷。
Cytotoxic dammarane glycosides from processed ginseng.
作者信息
Park Il Ho, Piao Long Zhu, Kwon Sung Won, Lee Yong Jae, Cho Sool Yeon, Park Man Ki, Park Jeong Hill
机构信息
College of Pharmacy, Seoul National University, South Korea.
出版信息
Chem Pharm Bull (Tokyo). 2002 Apr;50(4):538-40. doi: 10.1248/cpb.50.538.
Steaming ginseng at high temperature increased its cytotoxicity to SK-Hep-1 hepatoma cancer cells. HPLC separation and fractionation followed by MTT assay revealed that ginsenosides Rg3, Rg5, Rk1, Rs5, and Rs4 are the active principles. Their 50% growth inhibition concentration (GI50) values were 41, 11, 13, 37, and 13 microM, respectively. Cisplatin had a GI50 of 84 microM in the same assay conditions.
高温蒸制人参可增强其对SK - Hep - 1肝癌细胞的细胞毒性。通过高效液相色谱（HPLC）分离和分级，随后进行MTT分析表明，人参皂苷Rg3、Rg5、Rk1、Rs5和Rs4是活性成分。它们的50%生长抑制浓度（GI50）值分别为41、11、13、37和13微摩尔。在相同的测定条件下，顺铂的GI50为84微摩尔。
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