积雪草中两种新的达玛烷型单糖苷。

Two new dammarane monodesmosides from Centella asiatica.

作者信息

Weng Xiao-Xiang, Shao Yan, Chen Yun-Yan, Gao Wen, Cheng Liang, Kong De-Yun

机构信息

Department of Chinese Traditional Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, China.

出版信息

J Asian Nat Prod Res. 2011 Aug;13(8):749-55. doi: 10.1080/10286020.2011.588212.

DOI:10.1080/10286020.2011.588212

PMID:21751844

Abstract

Two new dammarane monodesmosides centellosides A (1) and B (2), and two new natural products ginsenosides Mc (10) and Y (11), together with 11 known compounds (3-9 and 12-15) reported for the first time from this genus, were isolated from the whole plants of Centella asiatica. All structures were elucidated by spectroscopic techniques and chemical methods, and compared with literature values. All the isolated compounds were evaluated in vitro for cytotoxicity.

摘要

从积雪草全草中分离得到两个新的达玛烷型单糖苷积雪草苷A（1）和B（2），以及两个新的天然产物人参皂苷Mc（10）和Y（11），同时还分离得到11个首次从该属植物中报道的已知化合物（3 - 9和12 - 15）。所有结构均通过光谱技术和化学方法进行了鉴定，并与文献值进行了比较。对所有分离得到的化合物进行了体外细胞毒性评价。