Nutman T B
Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0425, USA.
Curr Opin Infect Dis. 2001 Oct;14(5):539-46. doi: 10.1097/00001432-200110000-00006.
Although lymphatic filariasis remains among the major causes of disability among the tropical infectious diseases, dramatic advances have been made in the approach to its diagnosis, epidemiology and treatment, in our understanding of the molecular composition of the parasites that cause these infections, and in the factors underlying the pathology seen. Superimposing the tools of modern epidemiology, immunology, and molecular biology on field-based clinical trials has allowed the emergence of the concept of elimination of lymphatic filariasis. Much of the important new research emphasizes parasite development in the context of the host response, the importance of both the adult worm and other factors in the pathogenesis of lymphatic filarial disease, the role the Wolbachia endosymbiont holds as both a target for drug treatment and in inducing post-treatment reactions, and the various principles underlying the implementation of control programs.
尽管淋巴丝虫病仍是热带传染病中导致残疾的主要原因之一，但在其诊断、流行病学和治疗方法方面，在我们对引起这些感染的寄生虫分子组成的理解以及所见病理基础因素方面，都取得了显著进展。将现代流行病学、免疫学和分子生物学工具应用于基于现场的临床试验，使得淋巴丝虫病消除的概念得以出现。许多重要的新研究强调宿主反应背景下的寄生虫发育、成虫和其他因素在淋巴丝虫病发病机制中的重要性、沃尔巴克氏体共生菌作为药物治疗靶点以及诱导治疗后反应的作用，以及控制项目实施所依据的各种原则。
