Keiser Paul B., Nutman Thomas B.
Laboratory of Parasitic Diseases, Building 4, Room B1-05, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA. pkeise
Curr Infect Dis Rep. 2002 Feb;4(1):65-69. doi: 10.1007/s11908-002-0069-0.
Filarial infections remain significant causes of disability in tropical areas worldwide. However, insights into the developmental and molecular biology of the parasite and the immunobiology of the host response to infection have advanced our understanding, even as progress is being made towards implementing eradication programs. This article summarizes some of the recent advances in the understanding of filarial biology and parasite immune evasion mechanisms, and reviews those newer aspects of diagnosis and treatment most relevant to clinicians.
丝虫感染仍是全球热带地区导致残疾的重要原因。然而，尽管在实施根除计划方面取得了进展，但对该寄生虫的发育生物学、分子生物学以及宿主对感染反应的免疫生物学的深入了解，增进了我们的认识。本文总结了丝虫生物学及寄生虫免疫逃逸机制方面的一些最新进展，并综述了与临床医生最为相关的诊断和治疗的新进展。
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