Ogris Manfred, Wagner Ernst
Department of Pharmacy, Ludwig-Maximilians-Universität, München, Butenandtstrasse 5-13, D-81377 Munich, Germany.
Drug Discov Today. 2002 Apr 15;7(8):479-85. doi: 10.1016/s1359-6446(02)02243-2.
Targeting therapeutic genes to tumors is an attractive concept in curing malignant diseases. Systemic gene delivery systems are needed for therapeutic applications in which the target cells are not directly accessible, and which can only be reached via the systemic route. Recent developments in the field of non-viral gene delivery have shown that, based on (poly)cationic carrier molecules, DNA can be efficiently targeted to tumors via the bloodstream. Tailor-made synthetic vectors can be used to achieve predominant gene expression in tumor tissue. Therapeutic concepts based, for example, on suicide genes or cytokines, showed encouraging results in preclinical and also in first clinical evaluations.
将治疗性基因靶向肿瘤是治疗恶性疾病的一个有吸引力的概念。对于那些靶细胞无法直接接触，只能通过全身途径到达的治疗应用，需要全身基因递送系统。非病毒基因递送领域的最新进展表明，基于（聚）阳离子载体分子，DNA可以通过血液循环有效地靶向肿瘤。定制的合成载体可用于在肿瘤组织中实现主要的基因表达。例如，基于自杀基因或细胞因子的治疗概念在临床前和首次临床评估中都显示出令人鼓舞的结果。
