Azuma T, Suto H, Ito Y, Muramatsu A, Ohtani M, Dojo M, Yamazaki Y, Kuriyama M, Kato T
Second Department of Internal Medicine, Fukui Medical University, Matsuoka-cho, Yoshida-gun, Fukui, Japan.
Aliment Pharmacol Ther. 2002 Apr;16 Suppl 2:240-4. doi: 10.1046/j.1365-2036.16.s2.31.x.
The relationship between H. pylori infection and body mass indices is controversial.
To investigate the relationship between H. pylori infection and body indices, and to examine the effect of H. pylori eradication therapy on body indices.
Nine-hundred and thirty-two employees of an industrial corporation were examined for H. pylori infection and body mass indices. Three hundred and two H. pylori-positive cases diagnosed with chronic gastritis by upper gastrointestinal endoscopy or radiography underwent eradication therapy. Body mass indices, serum total cholesterol levels and symptom scores were obtained before and at 12 months after eradication therapy.
There was no significant difference in body weight, body mass index (BMI) or serum total cholesterol level between the H. pylori-positive and H. pylori-negative groups. However, body weight and BMI increased significantly 12 months after eradication of H. pylori infection. In contrast, there was no significant difference in body weight and BMI 12 months after eradication therapy in the non-eradication group. Serum total cholesterol levels did not change after eradication therapy in either the eradication or non-eradication groups.
Eradication of H. pylori infection induced an increase in BMI in industrial workers with chronic gastritis in Japan.
幽门螺杆菌感染与体重指数之间的关系存在争议。
研究幽门螺杆菌感染与身体指标之间的关系，并探讨幽门螺杆菌根除治疗对身体指标的影响。
对一家工业公司的932名员工进行了幽门螺杆菌感染和体重指数检查。通过上消化道内镜检查或放射学诊断为慢性胃炎的302例幽门螺杆菌阳性病例接受了根除治疗。在根除治疗前及治疗后12个月获取体重指数、血清总胆固醇水平和症状评分。
幽门螺杆菌阳性组和幽门螺杆菌阴性组在体重、体重指数（BMI）或血清总胆固醇水平方面无显著差异。然而，根除幽门螺杆菌感染12个月后体重和BMI显著增加。相比之下，未根除组在根除治疗12个月后体重和BMI无显著差异。根除组和未根除组在根除治疗后血清总胆固醇水平均未改变。
在日本患有慢性胃炎的产业工人中，根除幽门螺杆菌感染会导致BMI升高。
