The Effect of Eradication on Lipid Levels: A Meta-Analysis.

() infection is positively associated with cardiovascular diseases, but the involvement of lipids in this association remains unclear. The present study reviewed the changes in circulating lipid levels following eradication. A PubMed database was searched until December 2020 to identify randomized control trials (RCTs) and non-RCTs investigating the effect of eradication on the lipid levels in inverse variance-weighted, random-effects meta-analyses. A total of 24 studies (four RCTs and 20 non-RCTs) with 5270 participants were identified. The post-eradication levels were increased for high-density lipoprotein cholesterol (HDL-C; mean difference (MD) 2.28 mg/dL, 95% confidence interval (CI) 1.90 to 2.66) and triglyceride (TG; MD 3.22 mg/dL, 95% CI 1.13 to 5.31) compared with the pre-eradication levels. eradication resulted in little to no difference in the low-density lipoprotein-cholesterol levels (MD -2.33 mg/dL, 95% CI -4.92 to 0.26). In the analyses of RCTs only, the findings for elevated HDL-C levels, but not TG, were robust. eradication increases the HDL-C levels. Further studies are needed to elucidate the effects of lipid changes following eradication on cardiovascular diseases.