Parker Linda A, Mechoulam Raphael, Schlievert Coralynne
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario N2L 3C5, Canada.
Neuroreport. 2002 Apr 16;13(5):567-70. doi: 10.1097/00001756-200204160-00006.
Rats display conditioned rejection reactions during an oral infusion of a flavor previously paired with an emetic drug; considerable evidence indicates that these rejection reactions reflect nausea. Here we report that cannabidiol, a major non-psychoactive cannabinoid found in marijuana and its synthetic dimethylheptyl homolog interfere with nausea elicited by lithium chloride and with conditioned nausea elicited by a flavor paired with lithium chloride. These results suggest that cannabinoids without psychoactive side-effects may have therapeutic value in the treatment of chemotherapy-induced nausea.
大鼠在口服一种先前与催吐药物配对的味道时会表现出条件性排斥反应；大量证据表明这些排斥反应反映了恶心。我们在此报告，大麻二酚，一种在大麻中发现的主要非精神活性大麻素及其合成的二甲基庚基同系物，可干扰氯化锂引起的恶心以及与氯化锂配对的味道引起的条件性恶心。这些结果表明，无精神活性副作用的大麻素可能在治疗化疗引起的恶心方面具有治疗价值。
