Parker Linda A, Mechoulam Raphael
Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario.
Integr Physiol Behav Sci. 2003 Apr-Jun;38(2):133-45. doi: 10.1007/BF02688831.
Considerable evidence indicates that conditioned gaping in rats reflects nausea in this species that does not vomit. A series of experiments evaluated the potential of psychoactive cannabinoid agonists, delta-9-THC and HU-210, and non-psychoactive cannabinoids, Cannabidiol (CBD) and its dimethylheptyl homolog (CBD-dmh), to interfere with the establishment and the expression of conditioned gaping in rats. All agents attenuated both the establishment and the expression of conditioned gaping. Furthermore, the CB1 antagonist, SR-141716, reversed the suppressive effect of HU-210 on conditioned gaping. Finally, SR-141716 potentiated lithium-induced conditioned gaping, suggesting that the endogenous cannabinoid system plays a role in the control of nausea.
大量证据表明，大鼠的条件性张口反射反映了该物种不会呕吐的恶心感。一系列实验评估了精神活性大麻素激动剂Δ⁹-四氢大麻酚（delta-9-THC）和HU-210，以及非精神活性大麻素大麻二酚（Cannabidiol，CBD）及其二甲基庚基同系物（CBD-dmh）干扰大鼠条件性张口反射建立和表达的可能性。所有药物均减弱了条件性张口反射的建立和表达。此外，CB1拮抗剂SR-141716逆转了HU-210对条件性张口反射的抑制作用。最后，SR-141716增强了锂诱导的条件性张口反射，表明内源性大麻素系统在恶心控制中发挥作用。
