Aravich P F, Sclafani A, Leibowitz S F
Pharmacol Biochem Behav. 1982 Jan;16(1):101-11. doi: 10.1016/0091-3057(82)90020-x.
The relationship between the fiber systems involved in the hypothalamic noradrenergic feeding response and the medial hypothalamic (MH) hyperphagia syndrome was appraised in male rats using knife cuts. Parasagittal knife cuts in the perifornical hypothalamus produced hyperphagia and excessive weight gain but failed to disrupt feeding in response to paraventricular hypothalamic injections of norepinephrine (NE). Coronal knife cuts in the posterior hypothalamus which extended from the midline to the lateral perifornical region also failed to disrupt NE feeding. These findings indicate that the output of the noradrenergic feeding system does not follow the feeding pathway implicated in the MH hyperphagia syndrome. They also suggest that the output of the noradrenergic feeding system is not directed laterally beyond the level of the fornix nor caudally into the lower brainstem over the medial forebrain bundle.
利用刀切法，对雄性大鼠下丘脑去甲肾上腺素能摄食反应所涉及的纤维系统与下丘脑内侧（MH）食欲亢进综合征之间的关系进行了评估。在穹窿周下丘脑进行矢状旁切会导致食欲亢进和体重过度增加，但未能破坏对下丘脑室旁核注射去甲肾上腺素（NE）所产生的摄食反应。从下丘脑后部中线延伸至外侧穹窿周区域的冠状切也未能破坏NE诱导的摄食。这些发现表明，去甲肾上腺素能摄食系统的输出并不遵循与MH食欲亢进综合征相关的摄食途径。它们还表明，去甲肾上腺素能摄食系统的输出既不横向超出穹窿水平，也不通过内侧前脑束向尾侧延伸至下脑干。
