Jones R G, Booth D A
Physiol Behav. 1975 Jul;15(1):85-90. doi: 10.1016/0031-9384(75)90283-8.
Latencies to feed and meal sizes were observed in recently satiated rats injected intraperitoneally with an isotonic solution of 2-deoxyglucose, using 3-0-methyl glucose for the control injection. The feeding response latency shortened monotonically with dose from about 0.3 mmole/kg (50 mg/kg) to 0.5-0.6 mmole/kg, with an extended plateau up to dehilitating doses. At modest doses, the latency to feed was shorter in adrenal demedullated rats than in intact rats, suggesting that the hyperglycemic response to 2DG partially inhibits the feeding response. Food-deprived rats took larger meals following 2DG injection, if there had been recent rapid intestinal absorption of glucose. It is suggested that a major action of 2DG is to block the satiating consequences of the process of absorption, possibly at hepatic receptors.
给最近已饱足的大鼠腹腔注射2-脱氧葡萄糖等渗溶液，并使用3-0-甲基葡萄糖进行对照注射，观察其进食潜伏期和食量大小。进食反应潜伏期随剂量从约0.3毫摩尔/千克（50毫克/千克）单调缩短至0.5 - 0.6毫摩尔/千克，直至达到衰弱剂量前有一个延长的平台期。在中等剂量下，肾上腺去髓质大鼠的进食潜伏期比完整大鼠短，这表明对2DG的高血糖反应部分抑制了进食反应。如果近期葡萄糖在肠道快速吸收，饥饿大鼠在注射2DG后食量会增大。有人提出，2DG的主要作用可能是在肝脏受体处阻断吸收过程的饱腹感后果。
