Spruill Steven C, Kuller Jeffrey A
Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Obstet Gynecol. 2002 May;99(5 Pt 2):875-7. doi: 10.1016/s0029-7844(01)01603-9.
Wernicke's encephalopathy is usually associated with alcohol abuse, but can also occur with hyperemesis gravidarum. The effect of delay in thiamine replacement on fetal outcomes is unknown. We present a case of this complication.
A primipara with hyperemesis was admitted for mental status changes in her 14th week of pregnancy. Physical examination revealed a lethargic patient with ophthalmoplegia, ataxia, and hyporeflexia. Parenteral thiamine therapy was started. The patient improved rapidly although the ataxia persisted. A spontaneous abortion occurred 2 weeks later.
Wernicke's encephalopathy can complicate hyperemesis gravidarum. Early thiamine replacement may decrease the chances of spontaneous abortion.
韦尼克脑病通常与酒精滥用有关，但也可发生于妊娠剧吐。硫胺素替代治疗延迟对胎儿结局的影响尚不清楚。我们报告一例该并发症病例。
一名患有妊娠剧吐的初产妇在妊娠第14周因精神状态改变入院。体格检查发现患者嗜睡，伴有眼肌麻痹、共济失调和反射减退。开始进行胃肠外硫胺素治疗。患者迅速好转，尽管共济失调仍持续存在。两周后发生自然流产。
韦尼克脑病可使妊娠剧吐复杂化。早期补充硫胺素可能会降低自然流产的几率。
