Unger Evan C, Matsunaga Terry Onichi, McCreery Thomas, Schumann Patricia, Sweitzer Robert, Quigley Rachel
ImaRx Therapeutics, Inc., 1635 East 18th St., Tucson, AZ 85719, USA.
Eur J Radiol. 2002 May;42(2):160-8. doi: 10.1016/s0720-048x(01)00455-7.
Microbubbles, currently used as contrast agents have potential therapeutic applications. Microbubbles, upon insonation of sufficiently intense ultrasound will cavitate. Cavitation with microbubbles can be used to dissolve blood clots or deliver drugs. Targeting ligands and drugs can be incorporated into microbubbles to make highly specific diagnostic and therapeutic agents for activation with ultrasound. In this paper I will review some of these potential applications and experimental results using such agents for thrombolysis, drug and gene delivery.
目前用作造影剂的微泡具有潜在的治疗应用。在足够强度的超声照射下，微泡会发生空化。微泡的空化可用于溶解血凝块或递送药物。靶向配体和药物可被纳入微泡中，以制造用于超声激活的高度特异性诊断和治疗剂。在本文中，我将回顾其中一些潜在应用以及使用此类试剂进行溶栓、药物和基因递送的实验结果。
