Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, United States.
Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, Toyama, 930-0194, Japan.
Development. 2022 Apr 15;149(8). doi: 10.1242/dev.199908. Epub 2022 May 3.
The mechanisms underlying bone development, repair and regeneration are reliant on the interplay and communication between osteoclasts and other surrounding cells. Osteoclasts are multinucleated monocyte lineage cells with resorptive abilities, forming the bone marrow cavity during development. This marrow cavity, essential to hematopoiesis and osteoclast-osteoblast interactions, provides a setting to investigate the origin of osteoclasts and their multi-faceted roles. This Review examines recent developments in the embryonic understanding of osteoclast origin, as well as interactions within the immune environment to regulate normal and pathological bone development, homeostasis and repair.
骨发育、修复和再生的机制依赖于破骨细胞和其他周围细胞的相互作用和通讯。破骨细胞是具有吸收能力的多核单核细胞谱系细胞，在发育过程中形成骨髓腔。这个骨髓腔对造血和破骨细胞-成骨细胞相互作用至关重要，为研究破骨细胞的起源及其多方面的作用提供了一个环境。本综述检查了胚胎对破骨细胞起源的理解以及在免疫环境内的相互作用方面的最新进展，以调节正常和病理性骨发育、稳态和修复。
