Ellis D S, Stamford S, Tvoey D G, Lloyd G, Bowen E T, Platt G S, Way H, Simpson D I
J Med Virol. 1979;4(3):213-25. doi: 10.1002/jmv.1890040307.
The development of Marburg virus and the Sudanese and Zaire strains of Ebola virus in Vero cells as visualized by electron microscopy is described. Despite differences in timing, all three strains appear to pass through identical stages of development. Initially there is a large increase in nucleolus material, and viral precursor material arranges itself in spirals and then into tubes. The cells fill with core material, which passes to the plasmalemma, which often proliferates. Each virion passes through the plasmalemma, acquiring a coat of host material. The formation of torus forms is discussed; the branched appearance that is often seen is believed to be an aberrant form. The reasons for this view are put forward.
本文描述了通过电子显微镜观察到的马尔堡病毒以及埃博拉病毒苏丹株和扎伊尔株在非洲绿猴肾细胞中的发育情况。尽管在时间上存在差异，但所有三种毒株似乎都经历相同的发育阶段。最初，核仁物质大量增加，病毒前体物质呈螺旋状排列，然后形成管状。细胞充满核心物质，这些物质传递到质膜，质膜通常会增殖。每个病毒粒子穿过质膜，获得一层宿主物质包膜。文中讨论了环面结构的形成；通常所见的分支外观被认为是一种异常形式。并提出了支持这一观点的理由。
