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在酵母基因组中筛选新的DNA修复基因。

Screening the yeast genome for new DNA-repair genes.

作者信息

Jazayeri Ali, Jackson Stephen P

机构信息

Wellcome/Cancer Research UK Institute of Cancer and Developmental Biology and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.

出版信息

Genome Biol. 2002;3(4):REVIEWS1009. doi: 10.1186/gb-2002-3-4-reviews1009. Epub 2002 Mar 13.

DOI:10.1186/gb-2002-3-4-reviews1009
PMID:11983062
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC139348/
Abstract

Studies of DNA repair and the maintenance of genomic integrity are essential to understanding the etiology and pathology of cancer. The availability of the complete genome sequence of Saccharomyces cerevissiae has greatly facilitated the discovery of new genes important for DNA repair.

摘要

对DNA修复和基因组完整性维持的研究对于理解癌症的病因和病理至关重要。酿酒酵母完整基因组序列的可得性极大地促进了对DNA修复重要新基因的发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8c/139348/20b1fd3f8b29/gb-2002-3-4-reviews1009-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8c/139348/bba3bfdbb5ee/gb-2002-3-4-reviews1009-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8c/139348/20b1fd3f8b29/gb-2002-3-4-reviews1009-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8c/139348/bba3bfdbb5ee/gb-2002-3-4-reviews1009-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc8c/139348/20b1fd3f8b29/gb-2002-3-4-reviews1009-2.jpg

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本文引用的文献

1
NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae.NEJ1在酿酒酵母中控制非同源末端连接。
Nature. 2001 Dec 6;414(6864):666-9. doi: 10.1038/414666a.
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Genes required for ionizing radiation resistance in yeast.酵母中抗电离辐射所需的基因。
Nat Genet. 2001 Dec;29(4):426-34. doi: 10.1038/ng778.
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NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway.通过交配型对非同源末端连接（NHEJ）的调控是通过一种新的蛋白质Lif2p实现的，该蛋白质对连接酶IV途径至关重要。
异源表达的大肠杆菌基因如何有助于理解酿酒酵母中的DNA修复过程。
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Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast.Nej1p，酵母中非同源末端连接的细胞类型特异性调节因子。
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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.阿耳忒弥斯是一种新型的DNA双链断裂修复/V(D)J重组蛋白，在人类严重联合免疫缺陷中发生突变。
Cell. 2001 Apr 20;105(2):177-86. doi: 10.1016/s0092-8674(01)00309-9.
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A comprehensive two-hybrid analysis to explore the yeast protein interactome.一项探索酵母蛋白质相互作用组的全面双杂交分析。
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4569-74. doi: 10.1073/pnas.061034498. Epub 2001 Mar 13.
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Remodeling of yeast genome expression in response to environmental changes.酵母基因组表达响应环境变化的重塑。
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Functional analysis of the yeast genome by precise deletion and parallel phenotypic characterization.
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