首发精神分裂症和首发精神病性情感障碍患者胼胝体的形态差异
Shape differences in the corpus callosum in first-episode schizophrenia and first-episode psychotic affective disorder.
作者信息
Frumin Melissa, Golland Polina, Kikinis Ron, Hirayasu Yoshio, Salisbury Dean F, Hennen John, Dickey Chandlee C, Anderson Mark, Jolesz Ferenc A, Grimson W Eric L, McCarley Robert W, Shenton Martha E
机构信息
Consolidated Department of Psychiatry, Harvard Medical School and VA Boston Healthcare System-Brockton Division, 02301, USA.
出版信息
Am J Psychiatry. 2002 May;159(5):866-8. doi: 10.1176/appi.ajp.159.5.866.
OBJECTIVE
The corpus callosum, the largest white matter tract in the brain, is a midline structure associated with the formation of the hippocampus, septum pellucidum, and cingulate cortex, which have been implicated in the pathogenesis of schizophrenia. Corpus callosum shape deformation, therefore, may reflect a midline neurodevelopmental abnormality.
METHOD
Corpus callosum area and shape were analyzed in 14 first-episode psychotic patients with schizophrenia, 19 first-episode psychotic patients with affective disorder, and 18 normal comparison subjects.
RESULTS
No statistically significant corpus callosum area differences between groups were found, but there were differences in the structure's shape between the patients with schizophrenia and the comparison subjects. A correlation between width and angle of the corpus callosum was found in patients with affective disorder.
CONCLUSIONS
Corpus callosum shape abnormalities in first-episode psychotic patients with schizophrenia may reflect a midline neurodevelopmental abnormality.
目的
胼胝体是大脑中最大的白质束，是一种中线结构，与海马体、透明隔和扣带回皮质的形成相关，而这些结构已被认为与精神分裂症的发病机制有关。因此，胼胝体形状变形可能反映中线神经发育异常。
方法
对14例首发精神分裂症精神病患者、19例首发情感障碍精神病患者和18名正常对照受试者的胼胝体面积和形状进行分析。
结果
未发现各组之间胼胝体面积有统计学显著差异，但精神分裂症患者与对照受试者之间该结构的形状存在差异。在情感障碍患者中发现胼胝体宽度与角度之间存在相关性。
结论
首发精神分裂症精神病患者的胼胝体形状异常可能反映中线神经发育异常。
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