Almeida D, Antolín J, Amérigo M J, Cantabrana A, Roces A, Hayeck M
Servicio de Medicina Interna, Sección de Reumatología, Servicio de Análisis Clínicos, Complejo Hospitalario Ntra. Sra. de la Candelaria, Carretera del Rosario s/n, 38010 Santa Cruz de Tenerife.
An Med Interna. 2002 Feb;19(2):73-5.
a) to determine the prevalence of anti-ribosomal P antibodies in patients with ESL in our setting; b) to determine if there are associations between clinical signs of ESL and these autoantibodies; c) to analyze if there is any correlation between the presence of anti-P in patients with ESL and the results of other routine lab tests; and d) to assess the usefulness of implementing as routine test the determination of anti-P antibodies.
The study included 60 patients diagnosed of ESL and 61 healthy subjects as the control group. ELISA was used to determine anti-ribosomal antibodies. Chi-square, Fisher and Student t tests were used for the statistical analyses.
Of the 60 patients with SLE, 29 (48%) had anti-P antibodies as determined by ELISA. No association was observed between the presence of anti-P antibodies and psychosis, depression, hepatic failure, renal failure or any other clinical signs of ESL. A correlation was found between the levels of anti-P antibodies as determined by ELISA and anti-histone, ANA and AMA antibodies.
The prevalence of anti-P antibodies was high among our ESL patients (48%). Their presence was not significantly associated with any clinical sign; however, an association was found with other lab markers related to the presence of active disease.
a) 确定在我们的研究环境中，系统性红斑狼疮（ESL）患者抗核糖体P抗体的患病率；b) 确定ESL的临床体征与这些自身抗体之间是否存在关联；c) 分析ESL患者中抗P抗体的存在与其他常规实验室检查结果之间是否存在任何相关性；d) 评估将抗P抗体测定作为常规检查的实用性。
该研究纳入了60名被诊断为ESL的患者和61名健康受试者作为对照组。采用酶联免疫吸附测定（ELISA）法测定抗核糖体抗体。使用卡方检验、费舍尔检验和学生t检验进行统计分析。
在60名系统性红斑狼疮（SLE）患者中，通过ELISA测定，有29名（48%）患者存在抗P抗体。未观察到抗P抗体的存在与精神病、抑郁症、肝衰竭、肾衰竭或ESL的任何其他临床体征之间存在关联。通过ELISA测定的抗P抗体水平与抗组蛋白、抗核抗体（ANA）和抗线粒体抗体（AMA）之间存在相关性。
在我们的ESL患者中，抗P抗体的患病率较高（48%）。其存在与任何临床体征均无显著关联；然而，发现其与其他与活动性疾病存在相关的实验室标志物有关联。
