Kircher T T J, Liddle P F, Brammer M J, Williams S C R, Murray R M, McGuire P K
Department of Psychiatry, University of Tübingen, Germany.
Psychol Med. 2002 Apr;32(3):439-49. doi: 10.1017/s0033291702005287.
Formal thought disorder is a core symptom of schizophrenia. It is associated with a reversed lateralization of the superior temporal cortex volume, an area that is implicated in lexical retrieval. We investigated the neural correlates of word retrieval during continuous speech in patients with formal thought disorder using functional magnetic resonance imaging (fMRI).
Blood oxygenation level dependent (BOLD) contrast was measured with fMRI while six patients with schizophrenia and six healthy control subjects spoke about seven Rorschach inkblots for 3 min each. Subjects produced varying amounts of speech during each run. In a within subject design, the number of words produced was correlated with the BOLD contrast in the two runs in each participant who showed the highest variance of speech output.
In control subjects, the amount of speech produced was mainly correlated with activation in the left superior temporal gyrus. In the patient group, the main correlations were in the right superior temporal gyrus.
During the production of continuous speech, patients with formal thought disorder showed a reversed laterality of activation in the superior temporal cortex. This is consistent with findings of perturbed hemispheric interaction in schizophrenia, particularly in patients with formal thought disorder.
形式思维障碍是精神分裂症的核心症状。它与颞上叶皮质体积的侧化反转有关，该区域与词汇检索有关。我们使用功能磁共振成像（fMRI）研究了形式思维障碍患者在连续言语过程中词汇检索的神经相关性。
在fMRI测量血氧水平依赖（BOLD）对比时，六名精神分裂症患者和六名健康对照受试者分别就七张罗夏墨迹测验图说话，每次3分钟。在每次测试中，受试者产生的言语量各不相同。在受试者内设计中，在言语输出差异最大的每个参与者的两次测试中，产生的单词数量与BOLD对比相关。
在对照受试者中，产生的言语量主要与左侧颞上回的激活相关。在患者组中，主要相关性在右侧颞上回。
在连续言语产生过程中，形式思维障碍患者在颞上叶皮质表现出激活的侧化反转。这与精神分裂症中半球间相互作用紊乱的发现一致，特别是在形式思维障碍患者中。
