Greenwood I, Zakrzewska J M, Robinson P G
Dental Clinic, Mortimer Market Centre, Mortimer Market, London, UK.
Oral Dis. 2002 Mar;8(2):90-4. doi: 10.1034/j.1601-0825.2002.1o787.x.
To investigate changes in the prevalence of mucosal disease in patients with HIV/AIDS.
Retrospective analysis of clinic database.
An open-access dental clinic dedicated to the dental treatment of patients infected with HIV in London, UK.
Dental patients attending for routine assessment (check-up).
Prevalence of HIV associated oral lesions, diagnosed in accordance with EC classification criteria, in patients taking and not taking antiretroviral therapies (ARTs).
Data were collected at 2789 dental examinations for 1590 patients between 1992 and 1998. More patients taking ART had one or more oral manifestations in the years up to 1996, after which the prevalence fell to a similar level to those not taking medications. The prevalence of mucosal disease in patients not taking ART was relatively constant over time. These trends were observed for oral hairy leukoplakia, pseudomembranous and erythematous candidiasis and Kaposi's sarcoma but not for oral papillomata.
These data provide evidence that decreases in the prevalence of oral disease in people with HIV infection can be attributed to the effectiveness of ART.
调查人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）患者黏膜疾病患病率的变化情况。
对临床数据库进行回顾性分析。
英国伦敦一家专门为感染HIV患者提供牙科治疗的开放式牙科诊所。
前来进行常规评估（检查）的牙科患者。
根据欧洲共同体（EC）分类标准诊断的，正在接受和未接受抗逆转录病毒疗法（ART）的患者中与HIV相关的口腔病变患病率。
1992年至1998年间，对1590名患者进行了2789次牙科检查并收集了数据。在1996年之前，更多接受ART的患者出现了一种或多种口腔表现，此后患病率降至与未接受药物治疗的患者相似的水平。未接受ART的患者中黏膜疾病的患病率随时间相对稳定。这些趋势在口腔毛状白斑、假膜性和红斑性念珠菌病以及卡波西肉瘤中均有观察到，但口腔乳头状瘤未出现此趋势。
这些数据表明，HIV感染者口腔疾病患病率的下降可归因于ART的有效性。
