Kesner Raymond P, Gilbert Paul E, Barua Lindsay A
Department of Psychology, University of Utah, Salt Lake City 84112, USA.
Behav Neurosci. 2002 Apr;116(2):286-90. doi: 10.1037//0735-7044.116.2.286.
Memory for the temporal order of a sequence of odors was assessed in rats. A sequence of 5 odors mixed in sand was presented in digging cups, 1 at a time, to each rat in a sequence that varied on each trial. A reward was buried in each cup. After the 5th odor, 2 of the previous 5 odors were presented simultaneously; to receive a reward, the rat had to choose the odor that occurred earliest in the sequence. Temporal separations of 1, 2, or 3 represented the number of odors that occurred between the 2 odors in the sequence. Once a preoperative criterion was reached, each rat received a hippocampal (HIP) or cortical control lesion and was retested on the task. On postoperative trials, the HIP group was impaired relative to controls. However, the HIP group could discriminate between the odors. The data suggest that the hippocampus is involved in separating sensory events in time so that I event can be remembered separately from another event.
研究人员对大鼠气味序列的时间顺序记忆进行了评估。将5种混合在沙子中的气味依次呈现在挖掘杯中，每次向每只大鼠呈现1种气味，呈现顺序在每次试验中都不同。每种杯子中都埋有奖励。在呈现第5种气味后，同时呈现前5种气味中的2种；为了获得奖励，大鼠必须选择序列中出现最早的气味。时间间隔1、2或3代表序列中这2种气味之间出现的气味数量。一旦达到术前标准，每只大鼠接受海马体（HIP）或皮质对照损伤，并在该任务上重新测试。在术后试验中，海马体损伤组相对于对照组表现受损。然而，海马体损伤组能够区分不同气味。数据表明，海马体参与及时分离感觉事件，以便一个事件能够与另一个事件分开记忆。
