Luño E, Payer A R, Luengo J R, Del Castillo T B, Garcia V P
Department of Hematology, Hospital Central de Asturias, Oviedo, Spain.
Cancer Genet Cytogenet. 1998 Jan 1;100(1):84-7. doi: 10.1016/s0165-4608(97)00009-5.
We report a case of acute myeloid leukemia (AML) with trisomy 10 as the sole abnormality. We have observed this case among 202 de novo and untreated AML examined cytogenetically in our laboratory during the last 10 years. The patient was an adult man diagnosed with AML-M2. An interesting morphologic finding was the presence in light microscopy and ultrastructural studies of prominent giant "Chediak-Higashi-like" granules in some of the leukemic cells. Cell marker studies showed positivity for CD7 and CD33, as seen in the six previously reported cases. The prognosis has been moderate-good, with a survival of 33 months. Trisomy 10 in AML appears to be a rare recurring numeric chromosomal abnormality and probably linked to a myeloblast subset with a CD33+ and CD7+ phenotype.
我们报告了一例仅存在10号染色体三体这一异常情况的急性髓系白血病（AML）病例。在过去10年里，我们实验室对202例初发且未经治疗的AML进行了细胞遗传学检查，此病例即在其中。患者为一名成年男性，诊断为AML-M2。一个有趣的形态学发现是，在光学显微镜和超微结构研究中，部分白血病细胞内存在显著的巨大“类切-希二氏”颗粒。细胞标志物研究显示，如之前报道的6例病例一样，该病例的细胞对CD7和CD33呈阳性反应。预后为中度良好，生存期达33个月。AML中的10号染色体三体似乎是一种罕见的复发性数字染色体异常，可能与具有CD33+和CD7+表型的成髓细胞亚群有关。
