Maltau J M
Acta Obstet Gynecol Scand. 1975;54(4):357-61. doi: 10.3109/00016347509156767.
The frequency of marked fetal bradycardia (FB) during selective lumbar epidural anaesthesia with 0.25% or 0.5% bupivacaine (Marcain, Bofors) without adrenaline in doses of 5 ml to 8 ml is reported. 35 patients were monitored by means of the Hewlett-Packard Cardiotocograph with Hon's spiral scalp electrode and a transcervical catheter connected to a Hewlett-Packard (1280 B/C) physiological pressure transducer. Only patients with a normal cardiotocogram (CTG) before anaesthesia are included. During the second stage pathological fetal heart rate (FHR) patterns and technical artefacts are common, therefore the CTGs recorded in this period were not considered. In the 35 patients the total time of intrauterine monitoring was 119 hours. During this period 125 doses of 0.25% and 23 doses of 0.5% bupivacaine were given. In 33 parturients the FHR changes observed were insignificant. In one case a period of marked FB was seen. One parturient developed acute hypotension with a synchronous FB while lying in the supine position. It is concluded that continuous lumbar epidural anaesthesia with bupivacaine without adrenaline does not precipitate FB during the first stage when care is taken to avoid maternal hypotension.
本文报告了在选择性腰段硬膜外麻醉中,使用不含肾上腺素的0.25%或0.5%布比卡因(耐乐品,波福斯)5毫升至8毫升剂量时显著胎儿心动过缓(FB)的发生频率。35例患者通过惠普胎心监护仪、Hon氏螺旋头皮电极以及连接到惠普(1280 B/C)生理压力传感器的经宫颈导管进行监测。仅纳入麻醉前胎心监护图(CTG)正常的患者。在第二产程中,病理性胎儿心率(FHR)模式和技术伪差较为常见,因此该阶段记录的CTG未纳入分析。35例患者的宫内监测总时长为119小时。在此期间,给予了125剂0.25%布比卡因和23剂0.5%布比卡因。33例产妇观察到的FHR变化不显著。1例出现显著FB时段。1例产妇仰卧位时出现急性低血压并伴有同步FB。结论是,在第一产程中,若注意避免产妇低血压,使用不含肾上腺素的布比卡因持续腰段硬膜外麻醉不会引发FB。