Anversa P, Giacomelli J, Wiener J
Anat Rec. 1975 Nov;183(3):477-83. doi: 10.1002/ar.1091830311.
The ultrastructure of the intercellular junctions of rat endocardium has been characterized following lanthanum exposure in vitro and uranyl acetate staining en bloc. The interendothelial clefts of the endocardium run either a relatively straight or convoluted course and posses one or two loci where the plasma membranes are in close apposition or form punctate fusions. Elongate restrictions, that exhibit hexagonal arrays of subunits following lanthanum immersion (gap junctions), are also present in the intercellular endocardial clefts. The occurrence of interendothelial clefts of endocardium lacking occlusive foci can account for the permeability properties of ventricular endocardium, where the direction of diffusion of macromolecules has been attributed to pressure gradients between ventricular cavity and myocardium. The relationship of gap junctions to possible electrical phenomena within the endocardium is also discussed.
在体外暴露于镧并进行醋酸铀整体染色后，对大鼠心内膜细胞间连接的超微结构进行了表征。心内膜的内皮细胞间裂沟走行相对笔直或呈曲折状，有一个或两个位点，此处质膜紧密并列或形成点状融合。在镧浸入后呈现六边形亚基阵列的细长限制区域（缝隙连接）也存在于心内膜细胞间裂沟中。缺乏闭塞灶的心内膜内皮细胞间裂沟的存在可以解释心室心内膜的通透性特性，其中大分子的扩散方向归因于心室腔和心肌之间的压力梯度。还讨论了缝隙连接与心内膜内可能的电现象之间的关系。
