Avila Matthew T, McMahon Robert P, Elliott Amie R, Thaker Gunvant K
Maryland Psychiatric Research Center, University of Maryland, Baltimore 21228, USA.
J Abnorm Psychol. 2002 May;111(2):259-67.
Eye-tracking deficits in schizophrenic patients and relatives have generated interest in using eye movements to mark schizophrenia liability. Efforts to develop specific quantitative measures have provided insight into the nature of the deficit and suggested what underlying neurophysiological mechanisms are involved. This study used receiver operating characteristic curve analyses to evaluate and compare the sensitivity, specificity, and overall accuracy of predicting disease liability using single and combined specific and global quantitative measures. Results indicate that measures of predictive pursuit and leading saccades significantly increased predictive accuracy compared with traditional global measures. Combining specific measures provided greater predictive accuracy compared with single measures. Implications for the use of specific eye movement measures to define schizophrenia-related phenotypes in genetic studies are discussed.
精神分裂症患者及其亲属的眼动追踪缺陷引发了人们对利用眼动来标记精神分裂症易感性的兴趣。开发特定定量测量方法的努力为深入了解缺陷的本质提供了线索，并提示了其中涉及哪些潜在的神经生理机制。本研究使用受试者操作特征曲线分析来评估和比较使用单一及组合的特定和整体定量测量方法预测疾病易感性的敏感性、特异性和总体准确性。结果表明，与传统的整体测量方法相比，预测性追踪和引导性扫视的测量方法显著提高了预测准确性。与单一测量方法相比，组合特定测量方法可提供更高的预测准确性。本文讨论了在基因研究中使用特定眼动测量方法来定义精神分裂症相关表型的意义。
