Zhai Hongbo, Maibach Howard I
Department of Dermatology, University of California, School of Medicine, San Francisco 94143-0989, USA.
Skin Res Technol. 2002 Feb;8(1):1-6. doi: 10.1046/j.0909-752x.2001.10311.x.
BACKGROUND/AIMS: Skin occlusion may increase percutaneous absorption of applied chemicals, with some exceptions. It also obstructs the normal ventilation of the skin surface and increases stratum corneum hydration and hence compromises skin barrier function.
METHODS/RESULTS: This review focuses the effects of occlusion on skin barrier function, in particularly, as defined with objective skin bioengineering technology.
The effects of occlusion on skin barrier function have been defined with various techniques. Optimal hydrocolloid materials can absorb excess water and reduce the unfavourable effects of occlusion.
背景/目的：皮肤封闭可能会增加所涂抹化学物质的经皮吸收，但也有一些例外情况。它还会阻碍皮肤表面的正常通风，增加角质层水合作用，从而损害皮肤屏障功能。
方法/结果：本综述重点关注封闭对皮肤屏障功能的影响，特别是通过客观的皮肤生物工程技术所定义的影响。
已通过各种技术明确了封闭对皮肤屏障功能的影响。最佳的水胶体材料可以吸收多余的水分，并减少封闭的不利影响。
