Gaidamashvili M, van Staden J
Research Centre for Plant Growth and Development, School of Botany and Zoology, University of Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa.
J Ethnopharmacol. 2002 May;80(2-3):131-5. doi: 10.1016/s0378-8741(02)00011-9.
Lectin-like proteins from seven medicinal plant species of South Africa possessing well-documented antibacterial effects were examined for the interaction with two Gram-positive bacterial pathogens Staphylococcus aureus and Bacillus subtilis. Agglutinins elicited selective aggregation reactions with bacterial strains. Hypoxis hemerocallidea and Combretum mkhuzense agglutinins aggregated S. aureus at 4 and 5 microg ml(-1) of protein concentrations, respectively. B. subtilis was aggregated by C. mkhuzense, Kniphofia spp. and Tulbaghia violacea agglutinins at relatively high concentrations. The inhibition of bacterial growth at the initial stages of multiplication was observed in the presence of particular plant agglutinins. Suggestions are given about possible employment of agglutinins from medicinal plants in clinical microbiology. The possible contribution of lectin-like proteins to pharmacological effects associated with microbial infections is presumed.
对来自南非七种具有充分文献记载抗菌作用的药用植物物种的凝集素样蛋白，进行了与两种革兰氏阳性细菌病原体金黄色葡萄球菌和枯草芽孢杆菌相互作用的研究。凝集素引发了与细菌菌株的选择性聚集反应。仙茅属植物和南非风车子凝集素分别在蛋白质浓度为4和5微克/毫升时使金黄色葡萄球菌聚集。枯草芽孢杆菌在相对较高浓度下被南非风车子、火炬百合属植物和紫花郁金香凝集素聚集。在特定植物凝集素存在的情况下，观察到了细菌繁殖初期生长的抑制。文中给出了关于药用植物凝集素在临床微生物学中可能应用的建议。推测了凝集素样蛋白对与微生物感染相关药理作用的可能贡献。
