Ageev A K, Baliabin A A, Shipilov V M
Arkh Patol. 1975;37(5):21-9.
Analysis of prosector's findings and results of pathoanatomical studies of 65 cases who had died from sepsis showed that its incidence increased from 0.92% in 1956--1960 to 4.11% in 1971-1974. Along with the well-known typical manifestations of sepsis, a number of its perculiar features associated with application of modern therapeutic methods are considered: the prevailing form of sepsis is pyemia (81.5%), considerable incidence of sepsis following peritonitis and septic thrombophlebitis developing at sites of prolonged catheterization of veins. The significance of staphylococci and Bacillus pyocyaneus, which are resistant to the majority of the available at present antibiotics, as principle pathogenes of modern sepsis is emphasized. A dependence between the localization and size of metastatic foci and the kind of pathogene and nature of its toxines is noted. Among the conditions contributing to the development of sepsis the authors consider a reduction of the immunological reactivity of the organism morphologically characterized in the dead persons studied by the absence in lymphatic follicles of lymphatic nodes and the spleen, of "light" centres, drastic atrophic changes in the thymus gland in the majority of cases, and by slightly manifested phenomena of phagocytosis of microbes in the foci of inflammation. The role of operative and other traumas, the character of preceding diseases and application of immunodepressive therapy in the reduction of the immunological reactivity of the organism is tressed.
对65例死于败血症患者的尸体解剖结果及病理解剖学研究结果分析表明，其发病率从1956 - 1960年的0.92%增至1971 - 1974年的4.11%。除了败血症的常见典型表现外，还探讨了一些与现代治疗方法应用相关的特殊特征：败血症的主要形式是脓血症（81.5%），腹膜炎后败血症的发病率相当高，以及在长时间静脉插管部位发生的化脓性血栓性静脉炎。强调了对目前大多数可用抗生素耐药的葡萄球菌和铜绿假单胞菌作为现代败血症主要病原体的重要性。注意到转移灶的定位和大小与病原体种类及其毒素性质之间的相关性。在导致败血症发生的条件中，作者认为机体免疫反应性降低，在研究的死者中其形态学特征为淋巴结和脾脏的淋巴滤泡中缺乏“亮”中心，大多数病例中胸腺有严重萎缩性变化，以及炎症灶中微生物吞噬现象轻微。强调了手术及其他创伤、先前疾病的性质以及免疫抑制疗法在降低机体免疫反应性方面的作用。
