Kiebert Gwendoline, Sorensen Sonja V, Revicki Dennis, Fagan Susan C, Doyle Joseph J, Cohen Joel, Fivenson David
MEDTAP International, 7101 Wisconsin Avenue, Suite 600, Bethesda, MD 20814, USA.
Int J Dermatol. 2002 Mar;41(3):151-8. doi: 10.1046/j.1365-4362.2002.01436.x.
Although atopic dermatitis is a chronic skin disease that can have a major impact on a patient's life, the burden of illness associated with this condition has not been well characterized.
To determine the health-related quality of life (HRQL) of patients with atopic dermatitis by disease severity and to compare it with that of the general public and of patients suffering from other chronic illnesses or skin disorders.
Two hundred and thirty-nine atopic dermatitis patients aged 4-70 years completed the Medical Outcomes Study Short Form-36 Health Survey (SF-36) and the Dermatology Life Quality Index (DLQI) or the Children's Dermatology Life Quality Index. These HRQL scores were compared by self-reported patient disease severity ratings. Health-related quality of life scores were compared with those of the general population and those of patients with other chronic conditions (clinical depression, hypertension, type 2 diabetes) or skin disease (psoriasis). Dermatology Life Quality Index scores were also compared with those of other skin diseases (such as psoriasis, Darier's disease, and Hailey-Hailey disease).
Patients with atopic dermatitis had inferior scores on the SF-36 vitality, social functioning, and mental health subscales compared with individuals in the general population. In seven of eight subscales, individuals reporting more severe disease had inferior DLQI and SF-36 scores. Patients with atopic dermatitis had inferior mental health scores compared with those with diabetes or hypertension, and inferior social functioning scores compared with patients with hypertension. When compared with a psoriasis cohort, patients with atopic dermatitis had inferior scores in the role-physical, vitality, social functioning, role-emotional, and mental health SF-36 domains. Patients with atopic dermatitis had similar DLQI scores to patients with other chronic dermatologic diseases.
These results demonstrate that atopic dermatitis has an impact on HRQL, particularly in social functioning and psychological wellbeing. Patient-assessed severity of atopic dermatitis correlates with HRQL decrements, indicating greater HRQL impact with greater disease severity. Atopic dermatitis has as large an impact on HRQL as several chronic conditions and other dermatologic conditions.
虽然特应性皮炎是一种慢性皮肤病，会对患者生活产生重大影响，但与该病症相关的疾病负担尚未得到充分描述。
按疾病严重程度确定特应性皮炎患者的健康相关生活质量（HRQL），并将其与普通公众以及患有其他慢性疾病或皮肤疾病的患者进行比较。
239名年龄在4至70岁的特应性皮炎患者完成了医学结果研究简明健康调查（SF - 36）以及皮肤病生活质量指数（DLQI）或儿童皮肤病生活质量指数。这些HRQL分数通过患者自我报告的疾病严重程度评级进行比较。将健康相关生活质量分数与普通人群以及患有其他慢性疾病（临床抑郁症、高血压、2型糖尿病）或皮肤疾病（银屑病）的患者的分数进行比较。还将皮肤病生活质量指数分数与其他皮肤疾病（如银屑病、毛囊角化病和黑棘皮病）的分数进行比较。
与普通人群相比，特应性皮炎患者在SF - 36活力、社会功能和心理健康子量表上得分较低。在八个子量表中的七个中，报告疾病更严重的个体DLQI和SF - 36分数较低。与糖尿病或高血压患者相比，特应性皮炎患者心理健康得分较低，与高血压患者相比，社会功能得分较低。与银屑病队列相比，特应性皮炎患者在SF - 36的身体角色、活力、社会功能、情绪角色和心理健康领域得分较低。特应性皮炎患者的DLQI分数与其他慢性皮肤病患者相似。
这些结果表明，特应性皮炎会对HRQL产生影响，尤其是在社会功能和心理健康方面。患者评估的特应性皮炎严重程度与HRQL下降相关，表明疾病严重程度越高，对HRQL的影响越大。特应性皮炎对HRQL的影响与几种慢性疾病和其他皮肤病一样大。
