Luciani A, Kobeiter H, Maison P, Cherqui D, Zafrani E-S, Dhumeaux D, Mathieu D
Service de Radiologie et d'Imagerie Médicale, Hôpital Henri Mondor, Assistance Publique-Hôpitaux de Paris et Université Paris 12-Val de Marne, Créteil, France.
Gut. 2002 Jun;50(6):877-80. doi: 10.1136/gut.50.6.877.
Focal nodular hyperplasia (FNH) of the liver is a benign hepatic lesion relatively common in women. No studies specifically designed to describe the presentation and imaging findings in males have been published.
The aims of this study were: (a) to describe the clinical and imaging findings in 18 men with FNH, and (b) to compare these data with those observed in 216 women with FNH observed during the same nine year period.
According to a final diagnosis of FNH assessed either by pathological examination or by magnetic resonance (MR), the medical charts of 18 men with FNH observed at our institution were reviewed. In order to compare clinical and MR presentations, the files of 216 women with a total of 291 FNH lesions, investigated during the same nine year period, were reviewed.
Eighteen FNH lesions, with a mean diameter of 37.5 mm, were demonstrated in the 18 male patients. A total of 291 lesions with a mean diameter of 63.4 mm were comparatively demonstrated in 216 female patients. Mean age at diagnosis was significantly higher in men (p<0.01) and mean FNH size was significantly smaller in men (p<0.001). Surgery was more frequently performed in men (72.2%) than in women (16.7%) (p<0.001).
Our data indicate that FNH is rare in men and that the lesions are smaller and more often atypical than those in women.
肝脏局灶性结节性增生（FNH）是一种在女性中相对常见的良性肝脏病变。尚无专门描述男性患者表现及影像学特征的研究发表。
本研究的目的是：（a）描述18例男性FNH患者的临床及影像学表现；（b）将这些数据与同一9年期间观察到的216例女性FNH患者的数据进行比较。
根据病理检查或磁共振成像（MR）评估的FNH最终诊断结果，回顾了我院观察到的18例男性FNH患者的病历。为了比较临床和MR表现，回顾了同一9年期间调查的216例女性、共291个FNH病灶的档案。
18例男性患者共发现18个FNH病灶，平均直径37.5mm。216例女性患者共发现291个病灶，平均直径63.4mm。男性患者的诊断时平均年龄显著更高（p<0.01），男性FNH病灶的平均大小显著更小（p<0.001）。男性患者接受手术的比例（72.2%）高于女性患者（16.7%）（p<0.001）。
我们的数据表明，FNH在男性中罕见，且病灶比女性更小，更常表现为非典型。
