Department of Radiology, Duke University Medical Center, Durham, NC, 27710, USA,
Eur Radiol. 2011 Oct;21(10):2074-82. doi: 10.1007/s00330-011-2161-z. Epub 2011 Jun 28.
To retrospectively investigate the prevalence, MR findings, natural history, and association with other hepatic lesions of focal nodular hyperplasia (FNH)-like lesions in a cohort of consecutive patients with cavernous transformation of the portal vein (CTPV).
This retrospective IRB-approved study comprised 58 patients (32 men, 26 women; average age, 50 years) with CTPV who underwent liver MR imaging between 2000 and 2008. MR images were assessed by two radiologists in consensus for the presence of (a) FNH-like lesions and other liver lesions, and (b) other imaging findings. Patients were assigned to a stable or progressive clinical course based on lesion characteristics at follow-up.
Twelve of 58 patients (21%) had 38 FNH-like lesions (average size, 1.3 cm). Common findings of FNH-like lesions were isointensity on T2-weighted images (82%), intense and homogeneous enhancement during the arterial phase, and lack of washout during the hepatic venous and interstitial phases (100%). FNH-like lesions were found with other benign liver lesions (1 hemangioma, 1 adenoma) in two patients. Three (25%) patients with FNH-like lesions showed a progressive clinical course.
FNH-like lesions are commonly detected in patients with CTPV. Most lesions demonstrate benign imaging findings and stable clinical course.
回顾性研究在连续的门静脉海绵样变性（CTPV）患者队列中，局灶性结节性增生（FNH）样病变的发生率、MR 表现、自然病史以及与其他肝内病变的关系。
这项回顾性 IRB 批准的研究包括 58 例 CTPV 患者（32 名男性，26 名女性；平均年龄 50 岁），他们在 2000 年至 2008 年期间接受了肝脏磁共振成像检查。两名放射科医生通过共识评估了 MR 图像是否存在（a）FNH 样病变和其他肝脏病变，以及（b）其他影像学表现。根据随访时的病变特征，患者被分为稳定或进展的临床病程。
58 例患者中有 12 例（21%）有 38 个 FNH 样病变（平均大小 1.3cm）。FNH 样病变的常见表现为 T2 加权图像上的等信号强度（82%）、动脉期的强烈和均匀强化以及肝静脉和间质期的无洗脱（100%）。FNH 样病变与其他良性肝脏病变（1 个血管瘤，1 个腺瘤）一起在 2 例患者中发现。3 例（25%）FNH 样病变患者表现为进行性临床病程。
FNH 样病变在 CTPV 患者中常见。大多数病变表现出良性的影像学表现和稳定的临床病程。
