白细胞介素-18在宿主抵御播散性白色念珠菌感染中的作用。
Role of interleukin-18 in host defense against disseminated Candida albicans infection.
作者信息
Stuyt Rogier J L, Netea Mihai G, Verschueren Ineke, Fantuzzi Giamila, Dinarello Charles A, Van Der Meer Jos W M, Kullberg Bart Jan
机构信息
Department of Medicine, University Medical Center St. Radboud, Nijmegen, The Netherlands.
出版信息
Infect Immun. 2002 Jun;70(6):3284-6. doi: 10.1128/IAI.70.6.3284-3286.2002.
Abstract
In mice injected intravenously with Candida albicans, administration of anti-interleukin-18 (IL-18) antibodies increased the yeast load in the kidneys. There was no effect on the organ load with Candida when gamma interferon (IFN-gamma)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-gamma.
摘要
在静脉注射白色念珠菌的小鼠中，给予抗白细胞介素-18（IL-18）抗体可增加肾脏中的酵母负荷。当用抗IL-18抗体处理γ干扰素（IFN-γ）缺陷小鼠时，对念珠菌的器官负荷没有影响，这表明IL-18的保护作用是通过内源性IFN-γ介导的。
相似文献
1
Role of interleukin-18 in host defense against disseminated Candida albicans infection.
Infect Immun. 2002 Jun;70(6):3284-6. doi: 10.1128/IAI.70.6.3284-3286.2002.
2
Comparison of pathogenesis and host immune responses to Candida glabrata and Candida albicans in systemically infected immunocompetent mice.
Infect Immun. 2001 Aug;69(8):5046-55. doi: 10.1128/IAI.69.8.5046-5055.2001.
3
Endogenous interleukin (IL)-1 alpha and IL-1 beta are crucial for host defense against disseminated candidiasis.
J Infect Dis. 2006 May 15;193(10):1419-26. doi: 10.1086/503363. Epub 2006 Apr 4.
4
Recombinant interleukin-18 protects against disseminated Candida albicans infection in mice.
J Infect Dis. 2004 Apr 15;189(8):1524-7. doi: 10.1086/382955. Epub 2004 Apr 1.
5
The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures.
J Infect Dis. 2002 Apr 1;185(7):963-70. doi: 10.1086/339410. Epub 2002 Mar 11.
6
Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.
FEMS Immunol Med Microbiol. 2008 Jan;52(1):118-23. doi: 10.1111/j.1574-695X.2007.00353.x. Epub 2007 Nov 22.
7
Gamma interferon is not essential in host defense against disseminated candidiasis in mice.
Infect Immun. 1997 May;65(5):1748-53. doi: 10.1128/iai.65.5.1748-1753.1997.
8
9
Differential role of IL-18 and IL-12 in the host defense against disseminated Candida albicans infection.
Eur J Immunol. 2003 Dec;33(12):3409-17. doi: 10.1002/eji.200323737.
10
Exacerbation of invasive Candida albicans infection by commensal bacteria or a glycolipid through IFN-γ produced in part by iNKT cells.
J Infect Dis. 2014 Mar 1;209(5):799-810. doi: 10.1093/infdis/jit534. Epub 2013 Oct 4.
引用本文的文献
1
IL-18 production is required for the generation of a Th1 response during experimental chromoblastomycosis.
PLoS One. 2025 May 2;20(5):e0322127. doi: 10.1371/journal.pone.0322127. eCollection 2025.
2
A ketogenic diet enhances fluconazole efficacy in murine models of systemic fungal infection.
mBio. 2024 May 8;15(5):e0064924. doi: 10.1128/mbio.00649-24. Epub 2024 Apr 15.
3
The Role of B-Cells and Antibodies against Vaccine Antigens in Invasive Candidiasis.
Vaccines (Basel). 2021 Oct 10;9(10):1159. doi: 10.3390/vaccines9101159.
4
NLRC4 inhibits NLRP3 inflammasome and abrogates effective antifungal CD8 T cell responses.
iScience. 2021 May 18;24(6):102548. doi: 10.1016/j.isci.2021.102548. eCollection 2021 Jun 25.
5
Role for IL-1 Family Cytokines in Fungal Infections.
Front Microbiol. 2021 Feb 10;12:633047. doi: 10.3389/fmicb.2021.633047. eCollection 2021.
6
The Ubiquitin-Modifying Enzyme A20 Terminates C-Type Lectin Receptor Signals and Is a Suppressor of Host Defense against Systemic Fungal Infection.
Infect Immun. 2020 Aug 19;88(9). doi: 10.1128/IAI.00048-20.
7
Pattern recognition receptors in fungal immunity.
Semin Cell Dev Biol. 2019 May;89:24-33. doi: 10.1016/j.semcdb.2018.03.003. Epub 2018 Mar 9.
8
Integrating Inflammasome Signaling in Sexually Transmitted Infections.
Trends Immunol. 2016 Oct;37(10):703-714. doi: 10.1016/j.it.2016.08.004. Epub 2016 Aug 31.
9
Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1β production in response to β-glucans and the fungal pathogen, Candida albicans.
J Immunol. 2014 Sep 1;193(5):2519-2530. doi: 10.4049/jimmunol.1400276. Epub 2014 Jul 25.
10
Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.
PLoS Pathog. 2014 Jul 17;10(7):e1004276. doi: 10.1371/journal.ppat.1004276. eCollection 2014 Jul.
本文引用的文献
1
An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis.
J Immunol. 2000 Dec 1;165(11):6553-8. doi: 10.4049/jimmunol.165.11.6553.
2
Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice.
Infect Immun. 2000 Sep;68(9):5126-31. doi: 10.1128/IAI.68.9.5126-5131.2000.
3
Reduced host resistance and Th1 response to Cryptococcus neoformans in interleukin-18 deficient mice.
FEMS Microbiol Lett. 2000 May 1;186(1):121-6. doi: 10.1111/j.1574-6968.2000.tb09092.x.
4
Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection.
Infect Immun. 2000 May;68(5):2449-56. doi: 10.1128/IAI.68.5.2449-2456.2000.
5
Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: role of tumor necrosis factor alpha and IL-18.
Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2367-72. doi: 10.1073/pnas.040561297.
6
Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia.
J Immunol. 2000 Mar 1;164(5):2644-9. doi: 10.4049/jimmunol.164.5.2644.
7
IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor.
J Clin Invest. 1999 Sep;104(6):761-7. doi: 10.1172/JCI7501.
8
Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice.
Infect Immun. 1999 May;67(5):2585-9. doi: 10.1128/IAI.67.5.2585-2589.1999.
9
Interleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium.
Infect Immun. 1999 Feb;67(2):478-83. doi: 10.1128/IAI.67.2.478-483.1999.
10
Candidiasis in interferon-gamma knockout (IFN-gamma-/-) mice.
J Infect Dis. 1998 Aug;178(2):478-87. doi: 10.1086/515645.
Zotero 插件