Stuyt Rogier J L, Netea Mihai G, van Krieken Johan H, van der Meer Jos W M, Kullberg Bart Jan
Department of Medicine, University Medical Center St. Radboud, Nijmegen, The Netherlands.
J Infect Dis. 2004 Apr 15;189(8):1524-7. doi: 10.1086/382955. Epub 2004 Apr 1.
Endogenous interleukin (IL)-18 is necessary for host defense against candidiasis. Prophylactic treatment of Candida albicans-infected mice with recombinant murine (r) IL-18 decreased mortality, which was accompanied by a decreased outgrowth of yeasts in the kidneys 1 day after infection. Therapeutic administration of rIL-18 also resulted in decreased outgrowth of C. albicans in the kidneys and increased levels of interferon- gamma, both in the circulation and after in vitro stimulation of splenocytes with C. albicans. Histopathologic analysis of the kidneys showed increased inflammation and decreased growth of C. albicans in rIL-18-treated mice. In conclusion, rIL-18 improves outcome of disseminated candidiasis in mice and may prove useful as adjuvant immunotherapy of fungal infections.
内源性白细胞介素（IL）-18 是宿主抵御念珠菌病所必需的。用重组鼠（r）IL-18 对白色念珠菌感染的小鼠进行预防性治疗可降低死亡率，感染后 1 天，肾脏中酵母菌的生长也随之减少。rIL-18 的治疗性给药还导致肾脏中白色念珠菌的生长减少，循环中以及白色念珠菌体外刺激脾细胞后干扰素-γ 水平升高。肾脏的组织病理学分析显示，rIL-18 治疗的小鼠炎症增加，白色念珠菌生长减少。总之，rIL-18 可改善小鼠播散性念珠菌病的预后，可能作为真菌感染的辅助免疫疗法。
