Kloeze J, Abdellatif A M
Atherosclerosis. 1975 Nov-Dec;22(3):349-68. doi: 10.1016/0021-9150(75)90016-7.
Groups of metabolically normal (controls) and alloxan-diabetic adult female rabbits were fed semi-synthetic diets containing 40 cal % palm-kernel oil (PKO) or sunflower-seed oil (SSO) for 54 weeks. In contrast to control rabbits fed PKO-diet, the alloxan-diabetic rabbits on this diet, developed no or only a negligible degree of atherosclerosis, although the serum levels of all lipid classes had increased in the diabetic rabbits above that of the controls during almost the whole experimental period. The diabetic rabbits and the controls fed SSO-diet were both free from any significant atherosclerotic involvement in spite of the fact that the SSO-diet appeared unable to suppress the very high levels of the various serum lipid classes induced by the diabetic state. On both diets, the diabetic rabbits showed a significantly higher cholesteryl linoleate/oleate ratio than the controls, which was caused by an increase in the cholesteryl linoleate level in the diabetics. No serious aorta atherosclerosis was found in rabbits with a cholesteryl linoleate/oleate ratio higher than 0.6, although no correlation was found between the atherosclerosis indices and these ratios at values lower than 0.6. Rabbits with cholesteryl linoleate/oleate ratios below 0.6 seemed to run a greater risk of developing atherosclerosis. It is suggested that insulin might be required for atherogenesis in addition to hyperlipemia and hypercholesterolemia.
将成年雌性家兔分为代谢正常组（对照组）和四氧嘧啶糖尿病组，分别喂食含40%热量的棕榈仁油（PKO）或葵花籽油（SSO）的半合成饲料，持续54周。与喂食PKO饲料的对照家兔不同，喂食该饲料的四氧嘧啶糖尿病家兔未出现或仅出现程度可忽略不计的动脉粥样硬化，尽管在几乎整个实验期间，糖尿病家兔的所有血脂类别的血清水平均高于对照组。喂食SSO饲料的糖尿病家兔和对照家兔均未出现任何明显的动脉粥样硬化病变，尽管SSO饲料似乎无法抑制糖尿病状态诱导的各种血清脂质类别的极高水平。在两种饲料喂养下，糖尿病家兔的胆固醇亚油酸酯/油酸酯比值均显著高于对照组，这是由于糖尿病家兔胆固醇亚油酸酯水平升高所致。胆固醇亚油酸酯/油酸酯比值高于0.6的家兔未发现严重的主动脉粥样硬化，尽管在低于0.6的值时，动脉粥样硬化指数与这些比值之间未发现相关性。胆固醇亚油酸酯/油酸酯比值低于0.6的家兔似乎发生动脉粥样硬化的风险更大。研究表明，除高脂血症和高胆固醇血症外，动脉粥样硬化的发生可能还需要胰岛素。
