DUFF G L, BRECHIN D J, FINKELSTEIN W E
J Exp Med. 1954 Oct 1;100(4):371-80. doi: 10.1084/jem.100.4.371.
Experiments were undertaken to ascertain whether the previously demonstrated inhibition of the development of experimental aortic atherosclerosis in alloxan-diabetic rabbits fed cholesterol was due to the injection of alloxan per se or to the existence of the diabetic state produced by alloxan. It was established that, by treating the diabetic state with insulin, the diabetic state could be ameliorated and the inhibitory effect obviated. It was therefore concluded that the inhibitory phenomenon was not due to the injection of alloxan per se but that it was associated with one or more factors that characterize the alloxan diabetic state in the rabbit and that are reversible by insulin therapy. In the course of the experiment it was demonstrated that the inhibitory effect was apparent in cholesterol-fed diabetic rabbits whether or not their diet was supplemented with vegetable oil. The previously reported metabolic abnormalities of the diabetic animals were confirmed. It was established that suitable treatment of the cholesterol-fed diabetic animals with insulin would bring all the metabolic aberrations, including those of the serum lipids, into reasonably close correspondence with those observed in non-diabetic rabbits fed cholesterol.
进行了实验以确定先前在喂食胆固醇的四氧嘧啶糖尿病兔中所证明的实验性主动脉粥样硬化发展受抑制，是由于四氧嘧啶本身的注射，还是由于四氧嘧啶所产生的糖尿病状态。结果表明，通过用胰岛素治疗糖尿病状态，可以改善糖尿病状态并消除抑制作用。因此得出结论，抑制现象并非由于四氧嘧啶本身的注射，而是与兔四氧嘧啶糖尿病状态所特有的一个或多个因素有关，并且这些因素可通过胰岛素治疗逆转。在实验过程中表明，无论喂食胆固醇的糖尿病兔的饮食是否添加植物油，抑制作用都很明显。先前报道的糖尿病动物的代谢异常得到了证实。结果表明，用胰岛素对喂食胆固醇的糖尿病动物进行适当治疗，将使所有代谢异常，包括血脂异常，与喂食胆固醇的非糖尿病兔中观察到的情况相当接近。
