Zhang J, Li C, Guo X, Wang G
Department of Orthopectics and Thaumatology, Foshan Municipal Hospital of TCM, Guangdong, 528000.
J Tradit Chin Med. 2001 Dec;21(4):299-302.
To explore the effect of Buyang Huanwu Decoction (BHD) on platelet activating factor (PAF) content in arterial blood pre- and post-arterial thrombosis in rats, male Wistar rats were randomly divided into 3 groups, the medicine group treated with BHD, the control group with dexamethasone liquid, and the blank group with distilled water. Oral administration was given for 14 consecutive days, once daily. Model of arterial thrombosis was established in the animals 2 hours after final medication, the blood content of PAF, dry weight (DW) and occlusion time (OT) of thrombus, and dry weight of thrombus/body weight (TW/BW) ratio were observed. Results indicated that BHD could markedly lower the arterial blood content of PAF after thrombosis, increase the OT of thrombus, reduce the dry weight of thrombus and the TW/BW ratio (P < 0.05). It is suggested that BHD can inhibit the pathologic PAF metabolism and formation and development of arterial thrombus.
为探讨补阳还五汤对大鼠动脉血栓形成前后动脉血中血小板活化因子（PAF）含量的影响，将雄性Wistar大鼠随机分为3组，即补阳还五汤给药组、地塞米松液对照组和蒸馏水空白组。连续14天每日灌胃给药1次。末次给药2小时后造动脉血栓模型，观察血栓PAF含量、血栓干重（DW）、闭塞时间（OT）及血栓干重/体重（TW/BW）比值。结果显示，补阳还五汤可显著降低血栓形成后动脉血PAF含量，增加血栓OT，减轻血栓干重及TW/BW比值（P<0.05）。提示补阳还五汤可抑制病理性PAF代谢及动脉血栓的形成与发展。
