存活素在子宫颈上皮内瘤变及浸润性鳞状细胞癌中的表达

Expression of survivin in CIN and invasive squamous cell carcinoma of uterine cervix.

作者信息

Kim Han-Seong, Shiraki Katsuya, Park Sung-Hye

机构信息

Department of Anatomic Pathology, Inje University Ilsan Paik Hospital, Koyang City, Kyunggi-do, Republic of Korea.

出版信息

Anticancer Res. 2002 Mar-Apr;22(2A):805-8.

PMID:12014654

Abstract

BACKGROUND

Survivin is a novel member of the inhibitors of apotosis proteins (IAP). To evaluate the possible role of survivin in tumorigenesis of CIN (cervical intraepithelial neoplasia) and invasive squamous cervical carcinoma of the uterine cervix (SCC), the expression of survivin was studied.

MATERIALS AND RESULTS

In 41 CIN and SCC tissues, the expression of survivin, Fas-ligand, Fas and bcl-2 was studied by immunohistochemistry. Survivin expression tended to increase along with tumor progression; low-grade squamous intra-epithelial lesions (HSIL, CIN I), 66.7%, high-grade squamous epithelial lesions (HSIL, CIN II and III), 87.5% and SCC, 100% with a statistical significance (p<0.019). Alteration of Fas-ligand, Fas and bcl-2 expression was detected in 12.5%-25% of HSIL and in 7.7%-30.8% of SCC but no abnormal expression was found in LSIL.

CONCLUSION

Survivin expression seems to be more closely related to the progression of CIN and SCC compared to Fas-ligand, Fas and bcl-2.

摘要

背景

生存素是凋亡抑制蛋白（IAP）家族的一个新成员。为评估生存素在子宫颈上皮内瘤变（CIN）及子宫颈浸润性鳞状细胞癌（SCC）发生过程中的可能作用，对生存素的表达进行了研究。

材料与结果

采用免疫组织化学方法对41例CIN和SCC组织中生存素、Fas配体、Fas及bcl-2的表达进行研究。生存素的表达倾向于随肿瘤进展而增加；低度鳞状上皮内病变（HSIL，CIN I）中为66.7%，高度鳞状上皮内病变（HSIL，CIN II和III）中为87.5%，SCC中为100%，差异有统计学意义（p<0.019）。在12.5%-25%的HSIL及7.7%-30.8%的SCC中检测到Fas配体、Fas及bcl-2表达改变，但在低度鳞状上皮内病变（LSIL）中未发现异常表达。