Lee J-P, Chang K-H, Han J-H, Ryu H-S
Department of Obstetrics and Gynecology, Ajou University School of Medicine, University Hospital, 442-721, San 5, Wonchondong, Youngtong-ku, Suwon, Korea.
Int J Gynecol Cancer. 2005 Jan-Feb;15(1):113-9. doi: 10.1111/j.1048-891X.2005.15011.x.
A novel inhibitor of apoptosis, Survivin, seems to be involved in the critical steps of cancer onset and progression and may be associated with unfavorable clinical outcome. We investigated the expression of Survivin in patients with cervical intraepithelial neoplasia grade 3 (CIN3) and uterine cervical cancer, to determine whether Survivin expression is related to poor prognosis. Fourteen cases of CIN3, 53 cases of invasive uterine cervical squamous cell carcinoma (SCC), and 11 cases of normal control group were analyzed retrospectively. Immunohistochemical staining and Western blot was performed with antihuman Survivin antibody and analyzed with respect to patient outcome. Survivin was significantly expressed in cervical cancer groups compared to the normal control group (P < 0.05). Significant Survivin expression was also noted in cancer patients with lesion size > or =4 cm, lymphovascular invasion, elevated SCC antigen levels, and no response to initial therapy. In more advanced stages, Survivin expression tended to increase but without statistical significance (P = 0.081). No association was noted between Survivin expression and survival rate (P = 0.1011). We conclude that Survivin expression provides some prognostic information regarding uterine cervical cancer, even though it was not correlated with survival. It could represent a possible new prognostic marker of uterine cervical SCC patients.
一种新型凋亡抑制因子Survivin似乎参与了癌症发生和发展的关键步骤，并且可能与不良临床预后相关。我们研究了Survivin在宫颈上皮内瘤变3级（CIN3）患者和子宫颈癌患者中的表达情况，以确定Survivin表达是否与预后不良相关。回顾性分析了14例CIN3、53例浸润性子宫颈鳞状细胞癌（SCC）以及11例正常对照组病例。使用抗人Survivin抗体进行免疫组织化学染色和蛋白质印迹分析，并对患者预后进行分析。与正常对照组相比，Survivin在子宫颈癌组中显著表达（P < 0.05）。在病变大小≥4 cm、存在淋巴血管浸润、鳞状细胞癌抗原水平升高以及对初始治疗无反应的癌症患者中也观察到Survivin的显著表达。在更晚期阶段，Survivin表达有增加趋势，但无统计学意义（P = 0.081）。未发现Survivin表达与生存率之间存在关联（P = 0.1011）。我们得出结论，尽管Survivin表达与生存率无关，但它为子宫颈癌提供了一些预后信息。它可能代表子宫颈SCC患者一种可能的新预后标志物。
