Santy Lorraine C, Casanova James E
Department of Cell Biology, University of Virginia, Health Sciences Center, P.O. Box 800732, Charlottesville, Virginia 22908-0732, USA.
Curr Biol. 2002 May 14;12(10):R360-2. doi: 10.1016/s0960-9822(02)00860-6.
Membrane traffic and actin cytoskeleton dynamics are intimately linked, and GTPases of the Rho and ARF families may work together to regulate both. Recent studies have identified a family of GTPase activating proteins (GAPs) that contain both ARF-GAP and Rho-GAP domains, providing the first direct link between these two signaling pathways.
膜运输与肌动蛋白细胞骨架动力学密切相关，Rho和ARF家族的GTP酶可能共同作用来调节二者。最近的研究鉴定出了一类同时含有ARF-GAP和Rho-GAP结构域的GTP酶激活蛋白（GAP）家族，这为这两条信号通路之间提供了首个直接联系。
