Rainville Pierre
Département de Stomatologie, Faculté de Médecine Dentaire, Université de Montréal, CP 6128, Succursale Centre-ville, Montréal, Quebec H3C 3J7, Canada.
Curr Opin Neurobiol. 2002 Apr;12(2):195-204. doi: 10.1016/s0959-4388(02)00313-6.
Recent animal studies reveal ascending nociceptive and descending modulatory pathways that may contribute to the affective-motivational aspects of pain and play a critical role in the modulation of pain. In humans, a reliable pattern of cerebral activity occurs during the subjective experience of pain. Activity within the anterior cingulate cortex and possibly in other classical limbic structures, appears to be closely related to the subjective experience of pain unpleasantness and may reflect the regulation of endogenous mechanisms of pain modulation.
近期的动物研究揭示了上行伤害性感受通路和下行调节通路，这些通路可能导致疼痛的情感动机方面，并在疼痛调节中起关键作用。在人类中，疼痛的主观体验过程中会出现一种可靠的大脑活动模式。前扣带回皮质以及可能其他经典边缘系统结构中的活动，似乎与疼痛不适感的主观体验密切相关，并且可能反映了内源性疼痛调节机制的调控。
