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体内给予N，N-二[¹⁴C]甲基亚硝胺后大鼠肝脏染色质中DNA烷基化产物的异质性分布

Heterogeneous distribution of DNA alkylation products in rat liver chromatin after in vivo administration of N,N-di[14C]methylnitrosamine.

作者信息

Cooper H K, Margison G P, O'Connor P J, Itzhaki R F

出版信息

Chem Biol Interact. 1975 Dec;11(6):483-92. doi: 10.1016/0009-2797(75)90024-1.

DOI:10.1016/0009-2797(75)90024-1
PMID:1201613
Abstract

Poly-l-lysine (PL) binds to about 50% of chromatin DNA, rendering it resistant to degradation by DNAase I. Separation of the unbound DNA as acid-soluble nucleotides allows the fractionation of chromatin DNA into two zones. After in vivo administration of N,N-di[14C]methylnitrosamine, the amount of alkylation in DNA was found to be lower in the polylysine-binding regions. Some possible reasons for this heterogeneous distribution are discussed.

摘要

聚-L-赖氨酸（PL）与约50%的染色质DNA结合，使其对脱氧核糖核酸酶I的降解具有抗性。将未结合的DNA分离为酸溶性核苷酸，可将染色质DNA分馏成两个区域。在体内给予N，N-二[14C]甲基亚硝胺后，发现聚赖氨酸结合区域的DNA烷基化量较低。讨论了这种异质分布的一些可能原因。

相似文献

1
Heterogeneous distribution of DNA alkylation products in rat liver chromatin after in vivo administration of N,N-di[14C]methylnitrosamine.体内给予N，N-二[¹⁴C]甲基亚硝胺后大鼠肝脏染色质中DNA烷基化产物的异质性分布
Chem Biol Interact. 1975 Dec;11(6):483-92. doi: 10.1016/0009-2797(75)90024-1.
2
Phosphotriesters in rat liver deoxyribonucleic acid after the administration of the carcinogen NN-dimethylnitrosamine in vivo.在体内给予致癌物N-亚硝基二甲胺后大鼠肝脏脱氧核糖核酸中的磷酸三酯。
Biochem J. 1975 Mar;145(3):475-82. doi: 10.1042/bj1450475.
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Removal of methylated purines from rat liver DNA after administration of dimethylnitrosamine.给予二甲基亚硝胺后大鼠肝脏DNA中甲基化嘌呤的去除
Cancer Res. 1978 Jul;38(7):2011-7.
4
Methylation of DNAase-digestible DNA and of RNA in chromatin from rats treated with dimethylnitrosamine.用二甲基亚硝胺处理的大鼠染色质中可被脱氧核糖核酸酶消化的DNA及RNA的甲基化作用
Biochim Biophys Acta. 1979 Feb 27;561(2):334-44. doi: 10.1016/0005-2787(79)90142-4.
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Alterations in thermal stability of rat liver chromatin and DNA induced in vivo by dimethylnitrosamine and diethylnitrosamine.二甲基亚硝胺和二乙基亚硝胺在体内诱导大鼠肝脏染色质和DNA热稳定性的改变。
Cancer Res. 1978 Mar;38(3):510-5.
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Formation and subsequent removal of O6-methylguanine from deoxyribonucleic acid in rat liver and kidney after small doses of dimethylnitrosamine.小剂量二甲基亚硝胺作用后大鼠肝脏和肾脏中脱氧核糖核酸O6-甲基鸟嘌呤的形成及随后的去除
Biochem J. 1978 Sep 1;173(3):739-48. doi: 10.1042/bj1730739.
7
Effect of chronic administration of dimethylnitrosamine on the excision of O6-methylguanine from rat liver DNA.长期给予二甲基亚硝胺对大鼠肝脏DNA中O6-甲基鸟嘌呤切除的影响。
Cancer Lett. 1976 Nov;2(2):79-85. doi: 10.1016/s0304-3835(76)80015-8.
8
The induction of chromosomal damage in rat hepatocytes and lymphocytes. II. Alkylation damage and repair of rat-liver DNA after diethylnitrosamine, dimethylnitrosamine and ethyl methanesulphonate in relation to clastogenic effects.大鼠肝细胞和淋巴细胞中染色体损伤的诱导。II. 二乙基亚硝胺、二甲基亚硝胺和甲磺酸乙酯作用后大鼠肝脏DNA的烷基化损伤与修复及其与致断裂效应的关系
Mutat Res. 1983 Jan;107(1):153-66. doi: 10.1016/0027-5107(83)90085-4.
9
Studies on liver chromatin from rats treated with dimethylnitrosamine.对用二甲基亚硝胺处理的大鼠肝脏染色质的研究。
Biochim Biophys Acta. 1975 Oct 15;407(3):263-72. doi: 10.1016/0005-2787(75)90093-3.
10
Increased excision of O6-methylguanine from rat liver DNA after chronic administration of dimethylnitrosamine.长期给予二甲基亚硝胺后大鼠肝脏DNA中O6-甲基鸟嘌呤切除增加。
Cancer Res. 1979 May;39(5):1798-802.

引用本文的文献

1
The use of radioimmunoassay to study the formation and disappearance of O6-methylguanine in mouse liver satellite and main-band DNA following dimethylnitrosamine administration.使用放射免疫分析法研究二甲基亚硝胺给药后小鼠肝脏卫星DNA和主带DNA中O6-甲基鸟嘌呤的形成与消失。
J Cancer Res Clin Oncol. 1980;98(2):127-38. doi: 10.1007/BF00405957.
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DNA double-strand breaks induced in normal human cells during the repair of ultraviolet light damage.在正常人类细胞修复紫外线损伤过程中诱导产生的DNA双链断裂。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3619-23. doi: 10.1073/pnas.78.6.3619.
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Distribution of 7-methylguanine and of replication sites in the different kinetic classes of DNA from rats treated with dimethylnitrosamine.
用二甲基亚硝胺处理的大鼠不同动力学类别的DNA中7-甲基鸟嘌呤和复制位点的分布。
Nucleic Acids Res. 1978 Sep;5(9):3357-64. doi: 10.1093/nar/5.9.3357.
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The distribution of DNA repair synthesis in chromatin and its rearrangement following damage with N-acetoxy-2-acetylaminofluorene.N-乙酰氧基-2-乙酰氨基芴损伤后染色质中DNA修复合成的分布及其重排
Nucleic Acids Res. 1978 Sep;5(9):3261-73. doi: 10.1093/nar/5.9.3261.
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Dose-dependent preferential binding of polycyclic aromatic hydrocarbons to reiterated DNA of murine skin cells in culture.多环芳烃与培养的小鼠皮肤细胞重复DNA的剂量依赖性优先结合。
Proc Natl Acad Sci U S A. 1978 Dec;75(12):5841-5. doi: 10.1073/pnas.75.12.5841.