Zhang L Q, Laato M
Department of Medical Biochemistry, University of Turku, Turku, Finland.
Ann Chir Gynaecol Suppl. 2001(215):29-32.
The present study was designed to investigate the role of nerve elements in normal and aberrant human wounds, and in experimental rat wound healing model. The innervation of normal and hypertrophic human scars was studied using indirect immunofluorescence labeling with antibodies specific for neurofilament protein. Furthermore, ingrowth of axons into experimental rat wounds was assayed. The results demonstrated that, in contrast to normal wounds, hypertrophic scars were traversed by a high number of bundles of axons. Our results also demonstrated that experimental rat granulation tissue which represented early phases of wound healing attracted axonal growth. To conclude, our findings indicate that normal wound healing is accompanied with innervation of the scars, and that hypertrophy of scars is accompanied with hypertrophy of nerves within the scars. Our results also suggest that aberrations in the innervation of scars may either cause aberrant wound healing, or neural hypertrophy may be a result of disturbed interplay in wound healing mechanisms.
本研究旨在探讨神经成分在正常和异常人类伤口以及实验性大鼠伤口愈合模型中的作用。使用针对神经丝蛋白的特异性抗体进行间接免疫荧光标记，研究了正常和增生性人类瘢痕的神经支配情况。此外，还检测了轴突向实验性大鼠伤口的长入情况。结果表明，与正常伤口相比，增生性瘢痕中有大量轴突束穿过。我们的结果还表明，代表伤口愈合早期阶段的实验性大鼠肉芽组织吸引轴突生长。总之，我们的研究结果表明，正常伤口愈合伴随着瘢痕的神经支配，而瘢痕肥大伴随着瘢痕内神经的肥大。我们的结果还表明，瘢痕神经支配异常可能导致伤口愈合异常，或者神经肥大可能是伤口愈合机制中相互作用紊乱的结果。
