[鬼臼毒素糖苷自旋标记类似物的合成]
[Synthesis of spin labeled analogue of podophyllotoxin glycoside].
作者信息
Lu K, Chen Y
机构信息
Institute of Applied Pharmaceutical Research, Beijing Medical University, Beijing 100083.
出版信息
Yao Xue Xue Bao. 1998 Dec;33(12):948-50.
PMID:12016863
Abstract
A novel spin labeled analogue of podophyllotoxin glycoside 9 was synthesized by condensing 4'-demthyl-epipodophyllotoxin-beta-D-glucopyranose and 4-formyl-2, 2, 6, 6-tetrahydropuridine in presence of p-TsOH and triethyl orthoformate. It was shown to exhibit activity compatible to VP-16-213 in inhibiting L1210 cells.
摘要
通过在对甲苯磺酸和原甲酸三乙酯存在下，使4'-去甲基-表鬼臼毒素-β-D-吡喃葡萄糖苷与4-甲酰基-2,2,6,6-四氢吡啶缩合，合成了一种新型的鬼臼毒素糖苷9的自旋标记类似物。结果表明，它在抑制L1210细胞方面表现出与VP-16-213相当的活性。
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