Ramsey Scott D, Berry Kristin, Moinpour Carol, Giedzinska Antoinette, Andersen M Robyn
Department of Medicine, University of Washington, Seattle, USA.
Am J Gastroenterol. 2002 May;97(5):1228-34. doi: 10.1111/j.1572-0241.2002.05694.x.
We aimed to determine the quality of life (QOL) for long term survivors of colorectal cancer.
Persons with colorectal cancer who had survived at least 5 yr from diagnosis were recruited from a local cancer registry to answer questions about general QOL and colon cancer-specific issues. Before the general survey, focus group interviews with long term survivors were conducted to select survey questions from a pool of general and cancer-specific QOL questionnaires. The survey included the Health Utilities Index, the Center for Epidemiological Studies Depression Scale, and questions from the Short Form 36 and Functional Assessment of Cancer Therapy-Colorectal Cancer. After permission was obtained from their primary physicians, long term survivors from the registry were mailed invitation letters, then telephoned. Those agreeing were mailed self-administered questionnaires with stamped return envelopes.
Two hundred twenty-seven respondents (average age = 74 yr, 46% female) completed the survey. Survivors reported a relatively uniform and high QOL, irrespective of stage at diagnosis and time from diagnosis. Non-cancer related comorbid conditions and low income status had more influence on overall QOL than initial stage of colorectal cancer or time since diagnosis. Compared to age-matched populations, long term survivors reported higher overall QOL, but had higher rates of depression. Sixteen percent reported three or more bowel movements a day; 49% reported chronic recurrent diarrhea.
Those who achieve long term remission from colorectal cancer may experience a relatively high QOL, although physical symptoms such as diarrhea and depressive symptoms remain a problem.
我们旨在确定结直肠癌长期幸存者的生活质量（QOL）。
从当地癌症登记处招募自确诊后至少存活5年的结直肠癌患者，以回答有关一般生活质量和结肠癌特定问题。在进行全面调查之前，对长期幸存者进行了焦点小组访谈，以便从一系列一般和癌症特定的生活质量问卷中选择调查问题。该调查包括健康效用指数、流行病学研究中心抑郁量表，以及来自简短健康调查问卷36项和癌症治疗功能评估-结直肠癌的问题。在获得其主治医生的许可后，向登记处的长期幸存者邮寄了邀请信，然后打电话联系。同意参与的人会收到附带已付邮资回邮信封的自填式问卷。
两百二十七名受访者（平均年龄 = 74岁，46%为女性）完成了调查。无论诊断时的分期和诊断后的时间如何，幸存者报告的生活质量相对一致且较高。与结直肠癌的初始阶段或诊断后的时间相比，非癌症相关的合并症和低收入状况对总体生活质量的影响更大。与年龄匹配的人群相比，长期幸存者报告的总体生活质量较高，但抑郁症发病率较高。16%的人报告每天排便三次或更多次；49%的人报告有慢性复发性腹泻。
结直肠癌实现长期缓解的患者可能会有相对较高的生活质量，尽管腹泻等身体症状和抑郁症状仍然是个问题。
