蛋白酶体抑制剂的抗锥虫活性。
Antitrypanosomal activities of proteasome inhibitors.
作者信息
Nkemngu Njinkeng Joseph, Rosenkranz Vera, Wink Michael, Steverding Dietmar
机构信息
Abteilung Parasitologie, Hygiene-Institut. Institut für Pharmazeutische Biologie, Ruprecht-Karls-Universität, Heidelberg, Germany.
出版信息
Antimicrob Agents Chemother. 2002 Jun;46(6):2038-40. doi: 10.1128/AAC.46.6.2038-2040.2002.
Abstract
Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development.
摘要
测试了七种肽基蛋白酶体抑制剂对布氏锥虫血流形式的体外活性。两种化合物在低纳摩尔范围内显示出活性。总体而言，锥虫比人类HL-60细胞对这些化合物更敏感。这些数据支持蛋白酶体抑制剂在合理开发抗锥虫药物方面的潜力。
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本文引用的文献
1
Apoptosis in procyclic Trypanosoma brucei rhodesiense in vitro.无细胞体系体外培养的罗得西亚锥虫前cyclic 期细胞凋亡。
Cell Death Differ. 1996 Apr;3(2):229-36.
2
Ubiquitin proteasome pathway: implications and advances in cancer therapy.
Surg Oncol. 2001 Jul-Aug;10(1-2):43-52. doi: 10.1016/s0960-7404(01)00018-4.
3
In vitro effect of alkaloids on bloodstream forms of Trypanosoma brucei and T. congolense.生物碱对布氏锥虫和刚果锥虫血液形态的体外作用。
Planta Med. 2001 Oct;67(7):623-7. doi: 10.1055/s-2001-17351.
4
Proteasome inhibitors: from research tools to drug candidates.蛋白酶体抑制剂：从研究工具到候选药物
Chem Biol. 2001 Aug;8(8):739-58. doi: 10.1016/s1074-5521(01)00056-4.
5
Proteasome inhibitors: from in vitro uses to clinical trials.
J Pept Sci. 2000 Sep;6(9):478-88. doi: 10.1002/1099-1387(200009)6:9<478::AID-PSC285>3.0.CO;2-F.
6
Proteasome inhibitors as anti-cancer agents.
Anticancer Drugs. 2000 Jul;11(6):407-17. doi: 10.1097/00001813-200007000-00001.
7
Anti-sleeping sickness drugs and cancer chemotherapy.抗昏睡病药物与癌症化疗。
Parasitol Today. 2000 Jan;16(1):7-9. doi: 10.1016/s0169-4758(99)01560-4.
8
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Cancer Res. 1999 Jun 1;59(11):2615-22.
9
Programmed cell death in procyclic form Trypanosoma brucei rhodesiense --identification of differentially expressed genes during con A induced death.布氏罗得西亚锥虫前循环型细胞程序性死亡——刀豆球蛋白A诱导死亡过程中差异表达基因的鉴定
Mem Inst Oswaldo Cruz. 1999 Mar-Apr;94(2):229-34. doi: 10.1590/s0074-02761999000200020.
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Cell Death Differ. 1998 Jul;5(7):615-22. doi: 10.1038/sj.cdd.4400393.
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