Current indications for ACE inhibitors and HOPE for the future.

Angiotensin-converting enzyme (ACE) inhibitors are effective in several disease states such as congestive heart failure, myocardial infarction, and diabetes. This article reviews the evidence supporting the clinical use, efficacy, and cost effectiveness of ACE inhibitors in these various disease states. With the findings of the Heart Outcomes Prevention Evaluation trial, these agents may now have a positive impact on the primary prevention of coronary artery disease. New and ongoing trials will provide more information about the role of ACE inhibitors in coronary artery disease.