人肝脏中胆红素UDP-葡糖醛酸基转移酶活性的产前和产后发育以及早产对该活性的影响。
The prenatal and postnatal development of UDP-glucuronyltransferase activity towards bilirubin and the effect of premature birth on this activity in the human liver.
作者信息
Kawade N, Onishi S
出版信息
Biochem J. 1981 Apr 15;196(1):257-60. doi: 10.1042/bj1960257.
Abstract
Liver UDP-glucuronyltransferase activity towards bilirubin was studied in a total of 88 human subjects, including foetuses, premature and full-term newborn babies, infants, children, and adults. Determination of very low enzyme activity was performed by high-pressure liquid chromatography. Prenatal and postnatal changes of the activity can be divided into four developmental phases, i.e. middle foetal, late foetal, neonatal and early infantile, and mature. The activities of the first three phases corresponded to about 0.1, 0.1-1 and 1-100%, respectively, of the mature-phase values (mean +/- S.D.: 1320 +/- 514 microgram/h per g of liver, n = 27).
摘要
在总共88名人类受试者中研究了肝脏对胆红素的UDP - 葡萄糖醛酸基转移酶活性，这些受试者包括胎儿、早产和足月新生儿、婴儿、儿童及成人。通过高压液相色谱法测定极低的酶活性。该活性的产前和产后变化可分为四个发育阶段，即胎儿中期、胎儿晚期、新生儿期和婴儿早期以及成熟期。前三个阶段的活性分别约为成熟期值（平均值±标准差：每克肝脏1320±514微克/小时，n = 27）的0.1%、0.1 - 1%和1 - 100%。
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本文引用的文献
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High-pressure liquid chromatographic analysis of anaerobic photoproducts of bilirubin-IX alpha in vitro and its comparison with photoproducts in vivo.胆红素-IXα体外厌氧光产物的高压液相色谱分析及其与体内光产物的比较。
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The effect of premature and delayed birth on the development of UDP-glucuronosyltransferase activities towards bilirubin, morphine and testosterone in the rat.早产和晚产对大鼠胆红素、吗啡和睾酮的UDP-葡糖醛酸基转移酶活性发育的影响。
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