Wu Yikang
State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 354 Fenglin Road, Shanghai 200032, China.
Acc Chem Res. 2002 May;35(5):255-9. doi: 10.1021/ar000080b.
The antimalarial mechanism of qinghaosu (artemisinin) has been a problem since the late 1970s. During the past decade, several molecular level theories were postulated. However, their further development has been very difficult. By looking into the QHS cleavage process and all possible reaction paths available to the resulting transient radicals, the present commentary reveals those major hidden problems with the existing theories and tries to identify some essential features of the parasiticidal events that may take place within the intraerythrocytic malaria parasite. A seemingly more reasonable theory is also introduced.
自20世纪70年代末以来，青蒿素的抗疟机制一直是个问题。在过去十年中，人们提出了几种分子水平的理论。然而，它们的进一步发展非常困难。通过研究青蒿素的裂解过程以及由此产生的瞬态自由基可能的所有反应路径，本述评揭示了现有理论中那些主要的隐藏问题，并试图确定可能在红细胞内疟原虫体内发生的杀寄生虫事件的一些基本特征。还介绍了一种似乎更合理的理论。
