Wu Yikang, Liu He-Hua
State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China.
Chem Res Toxicol. 2003 Oct;16(10):1202-6. doi: 10.1021/tx034133k.
The radicals derived from qinghaosu (artemisinin) showed strong tendency for intramolecular reactions and thus are unlikely to cause so much damage to cells as simple alkyl radicals, giving a clue to the extraordinarily low toxicity of this radical precursor at therapeutic doses.
青蒿素衍生的自由基显示出强烈的分子内反应倾向，因此不太可能像简单烷基自由基那样对细胞造成如此大的损害，这为这种自由基前体在治疗剂量下极低的毒性提供了线索。
