探究抗疟过氧化物青蒿素（青蒿琥酯）高选择性毒性的可能分子起源。

Probing the possible molecular origin of the highly selective toxicity of antimalarial peroxide qinghaosu (artemisinin).

作者信息

Wu Yikang, Liu He-Hua

机构信息

State Key Laboratory of Bio-Organic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China.

出版信息

Chem Res Toxicol. 2003 Oct;16(10):1202-6. doi: 10.1021/tx034133k.

DOI:10.1021/tx034133k

PMID:14565761

Abstract

The radicals derived from qinghaosu (artemisinin) showed strong tendency for intramolecular reactions and thus are unlikely to cause so much damage to cells as simple alkyl radicals, giving a clue to the extraordinarily low toxicity of this radical precursor at therapeutic doses.

摘要

青蒿素衍生的自由基显示出强烈的分子内反应倾向，因此不太可能像简单烷基自由基那样对细胞造成如此大的损害，这为这种自由基前体在治疗剂量下极低的毒性提供了线索。