Wildberger Hannes, Junghardt Armin
Department of Ophthalmology, University of Zurich, Zurich, Switzerland.
Klin Monbl Augenheilkd. 2002 Apr;219(4):254-8. doi: 10.1055/s-2002-30653.
The value of multifocal electroretinography (mfERG) in the detection of localized retinal dysfunction in vascular branch disease at the posterior pole of the eye is investigated, and mfERG is compared with visual field defects.
10 eyes of 7 patients were tested, of which 8 eyes had a branch retinal vein occlusion and 2 eyes a branch artery occlusion. First order mfERG's were performed with the VERIS (TM) system, using 61 and 103 hexagons, and visual fields with the OCTOPUS M1 macular program. The number of hexagons with a response density loss (nV/deg (2)) of more than -2.0 standard deviations or of more than - 1.5 StDev, respectively, found in the normal population was compared with the number of disturbed test locations or total sensitivity loss (dB) of M1.
Local perimetric defects of various extent correlated well concerning localization and sensitivity loss with mfERG response density loss (nV/deg (2)). The best correlation was the total loss of M1 (dB) versus the number of hexagons out of 103, if the criterion of - 1.5 StDev was applied (p </= 0.001). In most cases, a diffuse but less severe response density loss of mfERG was also found at retinal places outside visual field defects and corresponding visible fundus changes.
Local visual field defects in retinal vascular branch occlusion correlate well with mfERG if suitable criteria are applied.
研究多焦视网膜电图（mfERG）在检测眼后极部血管分支疾病中局部视网膜功能障碍的价值，并将mfERG与视野缺损进行比较。
对7例患者的10只眼进行检测，其中8只眼为视网膜分支静脉阻塞，2只眼为视网膜分支动脉阻塞。使用VERIS（TM）系统进行一阶mfERG检查，采用61和103个六边形刺激，并用OCTOPUS M1黄斑程序进行视野检查。将在正常人群中分别发现的反应密度损失（nV/deg²）超过-2.0标准差或超过-1.5标准差的六边形数量，与M1的受干扰检查位置数量或总敏感度损失（dB）进行比较。
不同程度的局部视野缺损在定位和敏感度损失方面与mfERG反应密度损失（nV/deg²）相关性良好。如果采用-1.5标准差的标准，最佳相关性是M1的总损失（dB）与103个六边形中六边形数量的相关性（p≤0.001）。在大多数情况下，在视野缺损和相应可见眼底改变之外的视网膜部位也发现mfERG有弥漫但较轻的反应密度损失。
如果应用合适的标准，视网膜血管分支阻塞中的局部视野缺损与mfERG相关性良好。
